Correlation Between Serum Procollagen Type 1 N-Terminal Propeptide Level With Modified Rodnan Skin Score In Systemic Sclerosis Patients.
Introduction: Systemic Sclerosis (SSc) is a chronic
autoimmune disease, characterized by vasculopathy,
specific autoimmune, and fibrosis. Assesment of skin
fibrosis by modified Rodnan Skin Score (mRSS) can not
detect the minimal changes of skin fibrosis within less
than 3 months. A biomarker is needed to assess the
minimal changes of skin fibrosis progressivity with a
more objective, quantitative, and rapid way. Procollagen
type-1 N-Terminal Propeptide (P1NP), a degradation
product of collagen type-1, may become a potential
biomarker for skin fibrosis. This study aims to evaluate
the correlation between skin fibrosis by mRSS with
P1NP serum in systemic sclerosis.
Methods: This was a cross-sectional study performed
among systemic sclerosis patients at Rheumatology outpatient clinic, Dr.Hasan Sadikin Hospital Bandung, from
May 2016 to July 2016. Skin fibrosis was measured by
mRSS. P1NP level was determined by ELISA. Data were
analyzed using Rank-Spearman Correlation.
Result: There were thirty-seven subjects, with mean
age 37 (SD ±7) years old. Most of subjects were female (91.9%). Subjects consisted of 23 (62.2%) limited
SSc and 14 (37.8%) diffuse SSc. Six subjects (16.2%)
were DMARD naïve. We found median (range) P1NP
serum was 43.85 (9.81-127.90) ng/dL, while the median
of MRSS was 14 (3-36). There is a moderate correlation
between MRSS and P1NP serum (r=0.443, p=0.003)
Conclusion: There was a significant correlation
between mRSS and P1NP serum in systemic sclerosis
patient at Dr. Hasan Sadikin Hospital Bandung.
Keywords: systemic sclerosis, P1NP, modified rodnan
skin score.